Tadalafil

References

1. KD. Tripathi. Androgens and Drugs for Erectile Dysfunction. Essentials of medical pharmacology. Seventh edition. 2013. Page-304.

2. Adam M Henrie, James J Nawarskas, and Joe R Anderson. Clinical utility of tadalafil in the treatment of pulmonary arterial hypertension: an evidence-based review. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. November 2015. [Accessed on November 08th, 2023]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636095/

3. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed on November 08th, 2023]https://www.medicines.org.uk/emc/files/pil.8637.pdf

4. Leeford Healthcare Private Ltd. Bigfun-36.https://www.leeford.in/product/556/bigfun-36

5. Central Drugs Standard Control Organization. Tadalafil tablet 20 mg (Additional Indication). [Revised in November 2009]. Tadalafil 10mg/20mg Tablets. [Revised in September 2003] [Accessed on November 08th, 2023]https://cdscoonline.gov.in/CDSCO/Drugs

Asst. Drugs.https://www.accessdata.fda.gov/drugsat/drugsat-erectile-demand

6.https://www.cDsoc.gov.in/drugs/tadalafil/

Androgen Drug in Pulmonary Arterial Hypertension: A Systematic MEDLINE and PMC search using theatha.legraph.https://www.ncbi.nlm.nih.gov/pmc/articles/NB0544763/Desakespeare. Tadalafil 20mg Tablets. [Revised in November 2009] [Accessed on November 08th, 2023]https://www.bedford.com/pillss/drugss/tadalafil-gel-pill.aspxNordic Drugs (EU) Limited, The Nordic Pharmachemare (EU) and The Nordic Drugs (EU) reviewed the current state of the evidence on the safety and efficacy of tadalafil in the treatment of pulmonary arterial hypertension (PAH) in men aged 55 years and above. The studies they included were taken from the medical literature, with the exception of two that were considered of low quality. The following types of data were excluded from the analysis: results that did not specify an indication, results that did not specify an indication, results that did not specify an indication, conclusions that were unclear about the evidence, or conclusions that were too specific to the data. Further, men were required to have a medical history such as heart attack, angina, or stroke, liver or kidney disease, and taking phosphodiesterase type 5 inhibitors (PDE5-INH). Men who used tadalafil 20mg tablets in the previous 12 months were not eligible for the analysis if they had a previous history of heart attack, angina, or stroke. For this reason, the studies were not considered of low quality. There was no evidence that tadalafil 20mg could be used in patients with erectile dysfunction. In the event that a man had an erection that lasted longer than 4 hours (priapism), it was defined as an erection that lasted more than 4 hours and required medical treatment. Erectile dysfunction was not observed in the placebo group. Tadalafil 20mg was well tolerated and the majority of the patients (60%) were successful in achieving and maintaining an erection. Two patients in the tadalafil 20mg group and one in the placebo group required discontinuation due to side effects.

Whether you can take Tadalafil at the same time as your other medications will depend on which medications you are taking.

You are required to complete a short medical consultation questionnaire that asks for any medications that you are prescribed from your GP and will indicate the medications that can’t be taken alongside Tadalafil.

There are several medicines which should not be taken concurrently with Tadalafil. Medicines which can have potentially serious interactions with Tadalafil include :-

• Any alpha-blocker medicines e.g. doxazosin (Cardura), alfuzosin (Xatral), tamsulosin, terazosin, or Flomax, that you can buy in the pharmacy. (These medicines may be used to treat prostate problems or high blood pressure).

• Isosorbide mononitrate, isosorbide dinitrate, or use a GTN spray or tablets

for chest pain or use Rectogesic ointment?

• Nicorandil (Ikorel), used to treat angina

• Cimetidine, used to treat stomach or duodenal (peptic) ulcers

• Theophylline, used to treat asthma

• Antibiotics:- Clarithromycin, Erythromycin and Telithromycin

• Anti-fungals such as itraconazole and ketoconazole

• Seizure medication:- carbamazepine, oxcarbazepine, phenobarbital, phenytoin and primidone

• Heart or blood pressure medication:- disopyramide, amiodarone, quinidine and procainamide

• Anti-viral medication:- telaprevir, atazanavir, retonavir, indinavir, saquinavir and cobicistat

• Recreational drugs:- amyl nitrate (poppers)

If you are taking any prescribed medication from your GP then you can simply write those in the “Is there any other medical information that you think our doctor should know?” section on the medical questionnaire. Then, our doctor will know whether the Tadalafil is safe for you to take.

Read available consultation questionnaire information online for “Tadalafil is safe for use in pediatric patients with erectile dysfunction.”

You can see the medical questionnaire in online consultation in the top left corner of the page. In the other sections, “Is Tadalafil safe for use in patients with benign prostatic hyperplasia?” and “Is it safe to take Tadalafil in patients with pulmonary hypertension,” go to the medical questionnaire inline on the medical page. In addition, in addition to the medical questionnaire, you can read the medical questionnaire in the “Do you need medical advice from a doctor” section in the top right hand corner of the medical page. If in addition to the medical questionnaire, you have any other questions that are described in the “Is it safe to take” section in the medical questionnaire, then the full medical questionnaire will be available online for personal, honest information to discuss.

References

1. KD. Tripathi. Androgens and Drugs for Erectile Dysfunction. Essentials of medical pharmacology. Seventh edition. 2013. Page-304.

3. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed on November 08th, 2023]https://www.medicines.org.uk/emc/files/pil.8637.pdf

4. Leeford Healthcare Private Ltd. Bigfun-36.https://www.leeford.in/product/556/bigfun-36

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Recommended Citation
Greenhair, B. R. (2021). The tadalafil story. In: Takeda, K. Y., Y. Harada, K. S. Kamagai, and I. Iwanowiak (Eds.), 'The tadalafil story: A narrative of discovery and translation'. In: Y. Kamagai, I. Iwanowiak (Eds.), and T. Y. Gokpas (Macleod, NY), 957-966
fromIST.gov.in/default.cfmtoIST.gov.in/search/search/elaide
forSagar, Sanjeev
Frequently Asked Questions
What is the best way to buy tadalafil online?
Tadalafil is available as an oral tablet. You can buy it from your pharmacy, from a supermarket or from a online pharmacy.

References

1. KD. Tripathi. Androgens and Drugs for Erectile Dysfunction. Essentials of medical pharmacology. Seventh edition. 2013. Page-304.

3. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed on November 08th, 2023]https://www.medicines.org.uk/emc/files/pil.8637.pdf

4. Leeford Healthcare Private Ltd. Bigfun-36.https://www.leeford.in/product/556/bigfun-36

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Data Availability

All authors were provided data. The data are not publicly available. However, for academic research use, the data are available from the Public Health Service (PPS).

2.1. Investigational uses

2.1.1. Database requirements

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2.1.3. PubMed ()

2.1.4.

2.1.5.

2.1.6.

2.2.1. Inter-lider

2.2.2. Interlider ( collation )

PubMed () [Accessed on November 08th, 2023]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536095/

2.3. Search strategy

2.3.1.

Tadalafil belongs to the group of medicines called phosphodiesterase type 5 (PDE 5) inhibitors, primarily used to treat erectile dysfunction (impotence) and benign prostatic hyperplasia (BPH). Erectile dysfunction is the inability to keep a hard and erect penis suitable for sexual activity. Benign prostatic hyperplasia, also called prostate enlargement, is the non-cancerous growth of the prostate gland.

Tadalafil contains ‘Tadalafil’, which works by relaxing the blood vessels in the penis; this allows the blood to flow into the penis when the person is sexually excited. Thereby, it helps to treat erectile dysfunction. Tadalafil relaxes the bladder and prostate muscles, thereby reducing enlarged prostate symptoms such as difficulty in urination and urgent need to urinate.

You are advised to take Tadalafil for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as headache, back pain, muscle pain, pain in the legs and arms, nasal congestion, indigestion, and facial flushing. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take Tadalafil if you are taking nitrates (used to treat angina), riociguat (used to treat pulmonary hypertension) or alpha-blockers; if you have heart problems or stroke, low blood pressure or uncontrolled high blood pressure. Tadalafil is not intended for use in women. Tadalafil may cause dizziness, so drive with caution. Avoid consuming alcohol as it might cause increased dizziness. Tadalafil should not be given to children as safety and effectiveness have not been established. Keep your doctor informed about your health condition and the medicines you are taking to avoid unpleasant side effects.

Read the 'Instructions for Taking Tadalafil' and 'Do Not Take Tadalafil If You Are Taking Other Medications' toll during taking while taking Tadalafil and any risks and side effects you may experience. key Take take no more Tadalafilxtapids Tadalafil 2.5mg 20mg 5mg 2.5mg 5mg 5mg 5mg Tadalafil 2.5mg 2.5mg Tadalafil 2.5mg 5mg 5mg Tadalafil 2.5mg 5mg 2.5mg Tadalafil 2.5mg 5mg Tadalafil Tadalafil 20mg 2.

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